Endocrine Abstracts

Introduction: Precocious puberty in boys is the development of secondary sexual characteristics before 9 years of age. Peripheral precocious puberty (PPP), as opposed to central precocious puberty (CPP), is caused by autonomous secretion of androgens or human chorionic gonadotropin (hCG). Testicular volume, penis size, growth velocity, gonadotropin and androgen levels, and bone age readings aid in diagnosing precocious puberty and in identifying its cause. Distinguishing CPP f...

Aims: Several studies show a deficit in cortical bone in adults with Klinefelter syndrome (KS). A correlation between the adult cortical bone deficit and impaired bone accumulation during childhood or adolescence remains unclear. Therefore, we evaluated the cortical bone by automated digital X-ray radiogrammetry in KS children and adolescents and evaluated potential associations with hormonal, radiographic, and anthropometric factors implicated in bone mineral...

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Aims/hypothesis: The initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularization to improve engraftment has been attempted through virus-based delivery of angiogenic triggers, but risks associated with viral vectors have hampered clinical translation. In vitro transcribed mRNA transfection circumvents these risks and may be used for improving islet engraftment.Meth...